PCSK9 Inhibitors – a solution for familial hypercholesterolaemia and ischaemic heart disease?

Posted Leave a commentPosted in Biology, Health, Medicine

PCSK9 stands for Proprotein Convertase Subtilisin Kexin type 9 and it was first discovered in 2003[1] by Dr. Seidah et al. and it is a 692-amino acid glycoprotein.[2] PCSK9 is secreted by the liver into the circulation[3] and it controls the “number of low-density lipoprotein receptors (LDLR) on the cell surface”[4] and therefore ultimately the […]

Hypoplastic Left Heart Syndrome

Posted Leave a commentPosted in Biology, Health, Medicine

What is Hypoplastic left heart syndrome? Hypoplastic left heart syndrome (HLHS) is a rare congenital heart defect which occurs in approximately 1 in 5000 babies. The term ‘hypoplastic’ refers to the underdevelopment of a tissue or an organ. Therefore HLHS involves the underdevelopment, or sometimes absence, of left-sided heart structures. For example, the left ventricle, […]

Tetralogy of Fallot

Posted Leave a commentPosted in Biology, Health, Medicine

Tetralogy of Fallot What is Tetralogy of Fallot? Tetralogy of Fallot is a congenital heart defect (one which is present at birth.) In fact, it is one of the most common congenital heart defects. It affects approximately 5 in 10,000 live births. Fallot was the name of the doctor who discovered this condition and the […]