Human induced pluripotent stem cells (hIPSC) and their use on disease treatments
ABSTRACT Induced pluripotent stem cells (iPSCs) were discovered in 2006 by Shinya Yakama and his student Kazutoshi Takahashi in Japan. It was found out that, with the expression of only four genes, Oct3/4, Sox2, c-Myc and Klf4, somatic stem cells could be reprogrammed into the pluripotent-like state. This process was first made through the insertion …
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