Biochemistry

Human induced pluripotent stem cells (hIPSC) and their use on disease treatments

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ABSTRACT Induced pluripotent stem cells (iPSCs) were discovered in 2006 by Shinya Yakama and his student Kazutoshi Takahashi in Japan. It was found out that, with the expression of only four genes, Oct3/4, Sox2, c-Myc and Klf4, somatic stem cells could be reprogrammed into the pluripotent-like state. This process was first made through the insertion …

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Bifunctional molecules – A possible strategy for treating Hepatitis C viral infection

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Tavis Chen Abstract  Hepatitis C virus (HCV) treatment has improved over the past few years due to the development of antiviral drugs. Despite these advances, treatment remains generally expensive. One newly explored strategy to treat HCV infection is to neutralize a microRNA (miRNA) known as miRNA-122. miRNA-122 is involved in HCV development and neutralization of …

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